When I started running in 2002 I decided to take my choice of running shoes very seriously. I did a flow chart self-assessment and it revealed the need for motion control shoes. The recommendation of my local running shop was the Asics 21 series. Since then, I've had 2120, 2130, 40, 50 and now 2160s. They fit me like a glove and even at 16 stone they give me a wonderful ride.
I certainly wouldn't have been able to run 250K in ultra runs without them. No blisters, no problems. I would advise any runner to check their shoes. The time you take and the money you spend will pay massive dividends. You will still be in the running when others have given up.